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Effective products from Amaranthus spinosus L. and Portulaca oleracea L. for hemorrhoids

Thien Hoang Sa® supplement is formulated from bioactive substances extracted from Amaranthus spinosus L. and Portulaca oleracea L. which have therapeutic effects on hemorrhoids. It is the result of the scientific research work by Pharmacist-Dr. Nguyen Thi Ngoc Tram and her colleagues at home and abroad which has been started since 2007 up to now with the wish of searching for biologically active substances from Vietnamese medicinal herbs, helping patients to reduce the burden of treatment cost and get safe and effective treatment. 
 
Nearly 15 years of “Gestation”

It took Dr. Tram and her colleagues from the Bulgarian Academy of Sciences and the University of Innsbruck (Austria) a period of nearly 20 years to produce Crila® for the treatment of benign prostatic hyperplasia (BPH) and uterine fibroids. Not stopping there, she continued to search for new bioactive substances which have therapeutic properties against hemorrhoids from the rich source of Vietnamese precious herbs. She has successfully extracted these bioactive substances and formulated Thien Hoang Sa® capsule which is the second product arriving from the research work on Vietnamese herbs. It takes nearly 15 years for the study of Thien Hoang Sa® supplement.

Thien Hoang Sa® - a grain of golden sand from God

Thien Hoang Sa® supplement is the result of the ministry-level scientific research work: “Pre-clinical studies on Thien Hoang Sa capsule extracted from Vietnamese medicinal herbs for the treatment of hemorrhoids”. It is formulated from selected flavonoid fractions which are biologically effective against hemorrhoids. In the process of extraction, substances with undesirable adverse effects were removed from the extracts and the flavonoid fractions were purified to prepare herbal materials for the production of Thien Hoang Sa® capsules. Dr. Tram’s research work has discovered a new effect of Amaranthus spinosus L. on hemorrhoid treatment. The traditional remedies as well as the work “Vietnamese Traditional Medicinal Plants and Drugs” by Prof. Dr. Do Tat Loi have not written about the therapeutic properties of Amaranthus spinosus L. against hemorrhoids, but only folk remedies formulated from Portulaca oleracea L. which help cool down the body and treat constipation were mentioned. Thien Hoang Sa® capsules were studied on acute and subacute toxicity at the Department of Pharmacology – Hanoi University of Medicine by Assoc.Prof.Dr. Vu Thi Ngoc Thanh and under the consultancy of Prof.Dr. Dao Van Phan. The result showed that Thien Hoang Sa® capsule has no toxicity and does not affect the general condition of the body such as weight, hematopoiesis, liver function, kidney function and other organs of the patient’s body. It also meets the criteria of a hemorrhoid treatment medicine having the effects on vasoconstriction, promoting blood coagulation and hemostasis, increasing intestinal muscle tone, decreasing bowel movement, shrinking hemorrhoids, not affecting blood pressure and not prolonging the blood clotting time. So, patients can feel sure to use Thien Hoang Sa® supplement to support the treatment of internal hemorrhoids, external hemorrhoids and to prevent the hemorrhoids relapse after surgery. In order to select precious herbal materials from Amaranthus spinosus L. and Portulaca oleracea L. as raw materials for the production of Thien Hoang Sa® supplement to support hemorrhoid treatment, Dr. Tram and her colleagues conducted screening and studying the pharmaceutical effects of 13 extract samples of flavanoid fractions extracted from Amaranthus spinosus L., Portulaca oleracea L. and Houttuynia Cordata Thunb. The research results of 13 samples screened for effects on vascular smooth muscle, intestinal smooth muscle, bleeding time, clotting time, platelet counts, Prothrombin concentration and blood pressure showed that Amaranthus spinosus L. got 16 points, Portulaca Oleracea L. got 13 points and 11 points for Houttuynia Cordata Thunb. So, herbal materials for producing Thien Hoang Sa® supplement to support the treatment of hemorrhoids will be chosen from the samples with the highest score which are Amaranthus spinosus L. and then Portulaca Oleracea L. This is a scientific basis to demonstrate the difference between Thien Hoang Sa® supplement and other products which support the treatment of hemorrhoids available on the market that there is no composition of Houttuynia Cordata Thunb. in Thien Hoang Sa® supplement. Raw materials for the production of Thien Hoang Sa® supplement are herbal materials from Amaranthus spinosus L. and Portulaca oleracea L. which are cultivated and selected under GACP-WHO (Good Agriculture and Collection Practice – World Health Organization) criterion.

Proven high safety

Test results of acute toxicity in white mice and subacute toxicity in rabbits through oral administration demonstrated Thien Hoang Sa® capsule has no adverse impacts on the general condition; the growth rate of rabbits is still good; not altering the results of tests in evaluating hematopoietic function (erythrocyte count, hemoglobin concentration, hematocrit, mean erythrocyte volume, leukocyte count, leukocyte formula, platelet count); not altering the results of tests in evaluating liver function (ALT, AST, total bilirubin, protein, cholesterol) and renal function (creatinine); not causing significant damage in morphology when organs of rabbits were observed macroscopically. Microscopic structure of rabbit’s liver and kidney in two groups taking the test samples are in normal and undamaged condition.

After 2 weeks of withdrawal: general condition, the degree of weight gain of rabbits, evaluation tests of hematopoietic function, liver function, kidney function as well as the macroscopic observations of rabbit’s organs and microscopic structure of rabbit’s kidney showed no difference compared to the control groups.

So, although Thien Hoang Sa® capsules which have been studied on acute and subacute toxicity are proved free of toxicity and side effects, patients should read carefully the instructions of use available in the box. Thien Hoang Sa® - a golden sand of heaven has been “washed” from the rich source of Vietnamese herbs. This is the result of a hard sacrifice and great contribution to scientific research of Dr. Tram and her colleagues at home and abroad which help Vietnamese consumers to have a new medicinal herbal product supporting the treatment of hemorrhoids that is safe, effective and reasonable-priced for low-income people and contributing to add a new effect of Amaranthus spinosus L. and Portulaca oleracea L.


DONG HUONG

  In order to protect the copyright for new discoveries of disease treatment possibility of Amaranthus spinosus L. and Portulaca oleracea L., Pharmacist-Dr. Nguyen Thi Ngoc Tram has registered copyright for the scientific research project “Medicinal herbal product for the treatment of hemorrhoids formulated from bioactive flavonoids which are extracted from Amaranthus spinosus L. and Portulaca oleracea L.”  



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